Quantitative analysis of non-steroidal anti-inflammatory drugs by capillary zone electrophoresis

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Safety of non-steroidal anti-inflammatory drugs.

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in medical practice for treating pain, inflammation and degenerative joint diseases (for instance, arthritis). The use of traditional NSAIDs (tNSAIDs), however, is associated with an increased risk of minor and serious gastrointestinal (GI) events. It is estimated that in the European Union thousands of gastrointestinal complication...

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[Non-steroidal anti-inflammatory drugs (NSAIDs)].

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Accumulation of non-steroidal anti-inflammatory drugs by gingival fibroblasts.

Non-steroidal anti-inflammatory drugs (NSAIDs) are used to manage pain and inflammatory disorders. We hypothesized that gingival fibroblasts actively accumulate NSAIDs and enhance their levels in gingival connective tissue. Using fluorescence to monitor NSAID transport, we demonstrated that cultured gingival fibroblasts transport naproxen in a saturable, temperature-dependent manner with a K(m)...

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ژورنال

عنوان ژورنال: Journal of Pharmaceutical and Biomedical Analysis

سال: 1995

ISSN: 0731-7085

DOI: 10.1016/0731-7085(95)01339-m